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Why must glycogen control be manifested differently in muscle and liver?

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It is because the muscle maint...

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By what mechanism is phosphorylase kinase activated by Ca2+ levels of 1 μM?

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The δ subunit of phosphorylase kinase is...

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Which of the following occur after a carbohydrate-rich meal?


A) Blood-glucose levels increase leading to glycogen storage in the liver.
B) Blood-glucose levels increase leading to glycogen storage in the muscle.
C) Glucose uptake from the blood increases as a result of the action of insulin.
D) Glucagon is absent.
E) All of the answers are correct.

F) A) and D)
G) All of the above

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The key enzyme in regulation of glycogen degradation is


A) glycogen phosphatase.
B) glycogen phosphorylase.
C) glucose 1-phosphate synthase.
D) glycogen kinase.
E) None of the answers is correct.

F) All of the above
G) B) and D)

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______________ markedly stimulates glycogen breakdown in muscle by initiating a cAMP signal-transduction cascade.

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Epinephrin...

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In muscle,the first event in the breakdown of glycogen due to binding of a hormone is _____.


A) cytoplasmic cAMP levels rise
B) protein kinase A phosphorylates phosphorylase kinase
C) adenylate cyclase is activated
D) protein kinase A is activated
E) activation of a G protein

F) B) and C)
G) None of the above

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The key regulatory enzyme that primarily controls the rate of glycogen synthesis is


A) glycogen synthase phosphorylase.
B) glycogen synthase.
C) glycogen synthase kinase.
D) protein phosphatase-1.
E) None of the answers is correct.

F) B) and C)
G) A) and B)

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What physiological conditions render phosphorylase b less active?


A) High ATP, AMP, and glucose 6-phosphate levels
B) High ATP and low calcium ion levels
C) High ATP and glucose 6-phosphate levels
D) High AMP and low ATP levels
E) None of the answers is correct.

F) A) and E)
G) C) and D)

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Which of the following is a major site of glycogen storage?


A) adipose tissue
B) liver
C) pancreas
D) kidney
E) All of the answers are correct.

F) D) and E)
G) All of the above

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Phosphorylase requires the coenzyme ______________________ for activity.

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