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Some viruses are able to evolve at a fast rate,resulting in implications for


A) developing an effective immune response through vaccination.
B) treatment of the viral infection.
C) developing an immune response to the initial infection.
D) Both a and b are correct implications.
E) The implications in a,b,and c are all correct.

F) D) and E)
G) A) and B)

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Rhinovirus is a cause of the common cold.What type of infection does it usually cause?


A) acute
B) latent
C) persistent
D) latent or persistent,with equal likelihood
E) acute or latent,with equal likelihood

F) D) and E)
G) A) and C)

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If a newly discovered influenza-like virus has 15 neuraminidase proteins on its surface and 23 HA-like molecules,how many new strains could be generated through recombination?


A) 38
B) 144
C) 345
D) 1,000
E) This cannot be calculated due to the randomness of the process

F) A) and B)
G) A) and C)

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Translation inhibition by viruses can involve: (Select all that apply)


A) Cap-snatching from tRNA molecules
B) Cleavage of eIF-4B
C) Use of a fragment of eIF-4G to initiate viral mRNA translation
D) Addition of a cap from host mRNA onto a fully transcriibed viral mRNA
E) All are correct choices

F) C) and D)
G) All of the above

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The coronavirus that causes SARS is thought to have evolved from other coronaviruses through this process.


A) spontaneous mutation
B) recombination
C) errors in DNA replication
D) induced mutation
E) reassortment

F) A) and B)
G) C) and D)

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Some viruses cause certain types of cancer.

A) True
B) False

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True

The human immunodeficiency virus (HIV) can be transmitted by ALL of the following mechanisms EXCEPT:


A) through a mosquito bite.
B) mother to fetus.
C) blood transfusion.
D) sexual contact.
E) through breast milk.

F) A) and B)
G) A) and D)

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The Ebola virus is spread in several ways.Select all choices which are correct.


A) horizontal
B) vertical
C) vector
D) sexually
E) zoonotically

F) A) and E)
G) B) and E)

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This is an example of a virus known to undergo evolutionary change by reassortment.


A) influenza virus
B) papilloma virus
C) hepatitis type B virus
D) herpes virus
E) adenovirus

F) B) and D)
G) C) and E)

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A viral infection of short duration is referred to as a(n)________ infection.

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The Ebola virus is transmitted by a ____________ mechanism.


A) respiratory
B) zoonotic
C) fecal-oral
D) sexual
E) mechanical

F) B) and E)
G) A) and B)

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This viral infection results in the continuous production of virions over several years.


A) rhinovirus
B) myxoma virus
C) Hepatitis B virus
D) Ebola virus
E) influenza virus

F) A) and C)
G) C) and E)

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Viral infections are always acute and cause extensive damage to host cells.

A) True
B) False

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Epithelial cancer cells may arise when: (Select all that apply)


A) Adenoviral gene product E6 intereacts with Rb
B) Adenoviral gene product E7 intereacts with Rb
C) Adenoviral gene product E1B intereacts with p53
D) Adenoviral gene product E7 intereacts with p53
E) Adenoviral gene product E1A intereacts with Rb

F) A) and B)
G) A) and C)

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Why do RNA viruses have a high mutation rate?


A) Their RNA is a single stranded molecule.
B) Their RNA contains unusual nucleotides.
C) Their RNA-dependent RNA polymerases lack a proofreading function.
D) Their RNA is quickly degraded by nucleases.
E) Their RNA is not methylated after synthesis.

F) None of the above
G) A) and D)

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Genes whose alteration can transform normal cells into cancer cells are called ____________ .

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proto-onco...

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Oral herpes can be caused by: (Select all that apply)


A) HHV-1
B) HHV-2
C) HHV-3
D) HHV-4
E) HHV-5

F) A) and B)
G) A) and C)

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A,B

Abortive transformation of BRK epithelial cells may arise when:


A) None is a correct choice
B) Adenoviral gene product E7 intereacts with Rb
C) Adenoviral gene product E1B intereacts with p53 and Adenoviral gene product E1A intereacts with Rb
D) Adenoviral gene product E1B intereacts with Rb and Adenoviral gene product E1A intereacts with p53
E) Adenoviral gene product E1A intereacts with Rb

F) A) and C)
G) B) and D)

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The transmission of a virus from mother to fetus is referred to as ___________ transmission.

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vertical

Human epithelial cancer cells may arise when:


A) None is a correct choice
B) Adenoviral gene product E7 intereacts with Rb
C) Adenoviral gene product E1B intereacts with p53 and Adenoviral gene product E1A intereacts with Rb
D) Adenoviral gene product E1B intereacts with Rb and Adenoviral gene product E1A intereacts with p53
E) Adenoviral gene product E1A intereacts with Rb

F) All of the above
G) B) and E)

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